In Sharknado 5: Global Swarming (2017), Charo makes a cameo appearance as the Queen of England, adding to the film's ensemble of celebrity cameos. The movie features a range of high-profile personalities, including Fabio as the Pope and Chris Kattan as the Prime Minister of England, contributing to its over-the-top, satirical tone. As reported by E! Online, the film's tagline, "Make America Bait Again," reflects its campy and irreverent style, which is characteristic of the Sharknado franchise

Charo's role as the Queen of England is consistent with her long-standing public persona, characterized by flamboyance and humor. Her participation in this film aligns with her history of embracing comedic and unconventional roles in various media, including television appearances and reality shows. This cameo adds to her diverse portfolio of entertainment ventures, showcasing her versatility and willingness to engage with pop culture phenomena.

While Sharknado 5 received mixed reviews, it has found a niche audience appreciative of its campy and absurdist approach. Charo's appearance, along with other celebrity cameos, contributes to the film's appeal among fans who enjoy its satirical take on disaster movie tropes. Her involvement highlights her enduring presence in the entertainment industry and her ability to connect with contemporary pop culture.